Prescott LF, Roscoe P, Wright N, Brown SS. Drugs and other chemicals involved in fatal poisoning in England and Wales during 2000–2011.

Acute liver necrosis following overdose of paracetamol. Liver damage and impaired glucose tolerance after paracetamol overdosage. Medicine, poison, and mystic potion: a personal perspective on paracetamol Louis Roche lecture, Stockholm, 2009. This process is experimental and the keywords may be updated as the learning algorithm improves.īrodie BB, Axelrod J. These keywords were added by machine and not by the authors. Initial studies showed the relationship of plasma concentration of. In the 1970s there were a significant number of cases in the Royal Infirmary poisons unit in Edinburgh, and Laurie Prescott and colleagues did important work, allowing rapid progress in knowledge. At that time there were no effective therapies, and morbidity and mortality from acetaminophen overdose climbed steadily as overdoses increased (Fig. Toxicity from acetaminophen overdose was initially recognized in 1966, about 10 years after marketing, when the first cases were reported in Scotland. It was first marketed as an antipyretic and analgesic in the USA, as Tylenol, and UK, as Panadol, in the 1950s.

It was only when restudied in the late 1940s that it was recognized as safer than alternative agents. It was initially rejected in favor of the structurally related phenacetin, as it was considered too toxic. Acetaminophen (paracetamol) was first discovered in Germany in 1887.

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